The 'On the Floor' hitmaker shared a snap of herself back in the studio working on her tenth album on Thursday, posing with producer Cory Rooney and Brown, 23, reported Us magazine.
The 43-year-old mother of two looked happy as she leaned on the shoulder of the controversial "Don't Judge Me" singer, captioning the photo with hashtags "studiolife," "makinghistory," "Album10," and "SAMEGIRL."
One day earlier, Lopez was spotted leaving an Anaheim recording studio in sweats, sans makeup, surrounded by her staff and several pals.
Fans of Lopez responded to her post with excitement on Twitter.
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One said, "We're all dying to hear the result of all the hard work you're putting into Album10. We're ready to blow up the charts with you!
"I'm sure that album would be great! You've collaborated with great singers," another added.
Lopez has previously worked with the likes of Pitbull, Lil Wayne and Flo Rida on some of her chart-topping hits.