The local temple plans a four-day grand-opening ceremony to enshrine Venkateswara and his consorts - Sridevi, the goddess of wealth and Bhudevi, the goddess of Earth.
It will be "a state of the art temple, spread over at least 20,000 square feet with a capacity to accommodate at least 1,000 worshippers", said Ganesh Vathyam, a spokesperson of the temple committee.
"It will include an ornate, colourful towering entrance called "gopuram" and a brass or copper covered flagstaff called a "dwajasthambam", he added.
Plans are to bring sculptors from India to build the temple, and early projections place the cost at about USD 3 million, Vathyam said. A hope is that it will offer south-Indian heritage and culture to tourists from around the US, including people of other religions, Vathyam said.
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The temple is the second in Powell, Vathyam said. The Bharatiya Hindu Temple on Hyatts Road opened in 1994.
Ram Chandrasekar, a member of the temple committee, said the temple fulfills the aspirations of local Indians, many of whom are followers of Venkateswara.
Ohio is home to more than 74,000 Asian-Americans of Indian descent, according to a state report based on 2010 and 2013 US Census Bureau data. The state's Indian community has expanded by 80 per cent since 2000.