The 33-year-old, who has spoken out for the first time since the high-profile divorce from Hollywood superstar Tom Cruise, said the suffering of millions puts her problems in perspective, reported Sun online.
"I try to keep it all in perspective. There are a lot of people with much bigger problems and who are less fortunate," she said.
Holmes, who has just been announced as the first celebrity face of cosmetics firm Bobbi Brown, said that she has no regrets about her failed marriage.
The former 'Dawson's Creek' beauty said that she tries to do something new every day without being afraid to fail.
"Who cares? At least you tried. It's usually the people who haven't tried who are the naysayers," she said.
Holmes' divorce from "Top Gun" star Cruise was finalised last month. The couple were married for five years and have one child together, six-year-old daughter Suri.