The research, from Duke University in the US, found that participants reported a greater sense of spirituality shortly after taking oxytocin and a week later.
They also experienced more positive emotions during meditation, said lead author Patty Van Cappellen, a social psychologist at Duke.
"Spirituality and meditation have each been linked to health and well-being in previous research. We were interested in understanding biological factors that may enhance those spiritual experiences," Van Cappellen said.
"Spirituality is complex and affected by many factors. However, oxytocin does seem to affect how we perceive the world and what we believe," she added.
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Oxytocin occurs naturally in the body. Produced by the hypothalamus, it acts as a hormone and as a neurotransmitter, affecting many regions of the brain.
It is stimulated during sex, childbirth and breastfeeding. Recent research has highlighted oxytocin's role in promoting empathy, trust, social bonding and altruism.
To test how oxytocin might influence spirituality, researchers administered the hormone to one group and a placebo to another.
This was true after taking into account whether the participant reported belonging to an organised religion or not.
Participants who received oxytocin were also more inclined to view themselves as interconnected with other people and living things, giving higher ratings to statements such as "All life is interconnected" and "There is a higher plane of consciousness or spirituality that binds all people."
Study subjects also participated in a guided meditation. Those who received oxytocin reported experiencing more positive emotions during meditation, including awe, gratitude, hope, inspiration, interest, love and serenity.
Van Cappellen cautioned that the findings should not be over-generalised as there are many definitions of spirituality.
The study appears in the journal Social Cognitive and Affective Neuroscience.
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