Kishore Chandra Deo (Araku), M M Pallam Raju (Kakinada), Killi Kruparani (Srikakulam), Panabala Lakshmi (Bapatla) and Kotla Suryaprakash Reddy (Kurnool) lost their seats to their Telugu Desam and YSR Congress rivals.
Another former Union Minister Daggubati Purandeswari, who contested as the BJP candidate from Rajampet in Kadapa district, also faced defeat by a margin of over one lakh votes.
Compounding the misery of YSR Congress, that was trounced in the AP Assembly polls, its honorary president and president Y S Jaganmohan Reddy's mother, Y S Vijayamma, lost to BJP state president Kambhampati Hari Babu by a margin of over 60,000 votes in Visakhapatnam.
Kiran opted out of the electoral battle and fielded his brother at the last minute but could not escape the humiliation.
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All the Congress bigwigs, including its AP committee chief N Raghuveera Reddy, were mauled in the elections.
Former Finance Minister Anam Ramanarayana Reddy faced such a humiliating defeat in his native Atmakuru Assembly constituency that he lost his security deposit.
Former minister Galla Aruna Kumari, who joined TDP along with her industrialist-son Jayadev, faced defeat in their home constituency Chandragiri in Chittoor district.
But Jayadev, who made his political debut, won the Guntur Lok Sabha seat.
Former minister and former PCC president Botsa Satyanarayana's entire family had to bite the dust in their native Vizianagaram district, considered their fiefdom.
While Botsa lost the Assembly election from Cheepurupalle, his wife and MP Jhansi Rani was trounced in Vizianagaram parliamentary seat. Botsa's brother Appala Narasaiah and nephew Appalanaidu also lost the Assembly elections.