The 38-year-old "Fast and Furious" star visited the hospital with gifts and spent time with the patients and their parents, reported People magazine.
He also shared pictures from the festivities on Instagram.
"Tis the season. #givingback #childrenshospital #merryludacrismas @ludacrisfdtn," he captioned a photo collage with the kids and stuffed toys.
He tagged his charity organization, The Ludacris Foundation, which he started in December, 2001.
"Making their day makes my day @ludacrisfdtn #merryludacrismas," he captioned another photo.
"To all the parents my heart & prayers are with you. To all the children I admire your strength and perseverance. Love from the @ludacrisfdtn #childrenshospital #merryludacrismas," he wrote along side a picture with the parents of the kids.