The scrip plummeted by 13.45 per cent to Rs 1,294.05, its 52-week low, on BSE.
On NSE, shares of the company tanked 14.38 per cent to hit its one-year low of Rs 1,280.
The counter was the worst performer among the blue-chips on both Sensex and Nifty.
At present, the company has a market valuation of Rs 62,227.76 crore.
Meanwhile, BSE has sought clarification from Lupin with reference to the news about Mandideep unit, inspected by the USFDA from February 8-19, 2016, and that the observations are serious in nature.