The stock dipped 5.23 per cent to Rs 1,728.60 on the BSE. During the day, it lost 5.92 per cent to Rs 1,716.
The stock was the top loser among the 30-blue-chip Sensex components.
At the NSE, shares of the company slipped 5.24 per cent to Rs 1,728.25.
The company's market valuation declined by Rs 4,293.91 crore to Rs 77,767.09 crore.
"For Q1 FY16, the company announced numbers lower than expected," said Sarabjit Kour Nangra, VP Research - Pharma, Angel Broking.
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The company had posted a Net profit, after taxes and minority interest, of Rs 624.74 crore for the corresponding period of the previous fiscal, Lupin said in a filing to BSE.
Consolidated total income from operations also witnessed a decline to Rs 3,150.23 crore during the quarter under review as against Rs 3,340.82 crore for the same period a year ago.
The company's revenue within India rose to Rs 993.56 crore for the June quarter from Rs 865.11 crore during the year-ago period.