The Oscar-winning star will play Noah's Mother, Patricia, in the adaptation of "Born a Crime: Stories from a South African Childhood".
"When I read @Trevornoahs Born A Crime, I could not put the book down. Excited to announce that I will be starring in and producing its feature film adaptation!," she wrote on Twitter.
Noah will also produce the project through his Ark Angel Productions alongside Norman Aladjem, Derek Van Pelt and Sanaz Yamin of Mainstay Entertainment, and Nyong'o, reported Deadline.
It also details Noah's relationship with his fearless, rebellious, and fervently religious mother, who was determined to save her son from the cycle of poverty, violence and abuse.
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The 'Daily Show' host, the son of a white Swiss father and a black Xhosa mother, said his mother kept him hidden in his early years as such a union was punishable by five years in prison in the country.
Nyong'o won an Oscar for her role in "12 Years a Slave" and currently stars in "Black Panther" as Nakia, the love interest of King TChalla and a warrior in her own right.