Mysura, who has been a key strategist for the YSRC, emailed his resignation letter to Jagan this morning.
"He (Jagan) doesn't take others' opinion into consideration. He himself lacks consistency," Mysura told reporters today after quitting the party.
"Except money, there is no value for anything in the YSRC. Jagan craves only for power. He doesn't have a human angle," Mysura, who previously served in the Congress and the Telugu Desam Party, said.
Mysura said being an Opposition party, the YSRC did not have any inclination to stand by the people and fight for their causes.
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"Jagan doesn't have any belief in democracy. The happenings in the YSRC only denote that everything is guided by vested interests," Mysura said.
"As a senior politician, I used to take the initiative and offer advice when required but Jagan never took it," he lamented.
A former state Home Minister and a former member of Rajya Sabha, Mysura shared a 'love-hate relationship' with Jagan's father late Y S Rajasekhara Reddy.
He even contested the Lok Sabha by-election from Kadapa in 2011 against Jagan and lost.