The 37-year-old actor began his Twitter-spree by announcing that he would not be watching the 2018 Oscars.
"I will be live tweeting the Oscars tonight, but I won't be watching them. WHAT! That's crazy!" he posted on Twitter.
Culkin then went on to write series of messages aimed at male actors tied to sexual harassment charges within the entertainment industry. He started with Harvey Weinstein and Kevin Spacey.
"EXCLUSIVE: I heard Kevin Spacey and Harvey Weinstein were going to come disguised as a very tall man in a long trench coat but they got busted by security," he posted.
Targetting Franco, Culkin tweeted, "James Franco is a disaster. Artists? 'The Disaster Artist' was the worst harry potter movie this year.
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