Nic Maddinson on Saturday pulled out of Australia A's clash against Pakistan in Perth on mental health grounds, all-but ruling him out of contention for a berth in the Test squad.
The middle-order batsman's decision comes barely a week after Glenn Maxwell withdrew from Australia's Twenty20 team to deal with similar issues.
Cameron Bancroft will replace Maddinson for the three-day match against Pakistan at Perth Stadium from Monday.
"Nic has made the right decision and we are all behind him," said Australia A coach Graeme Hick.
"It is braver to speak up than to suffer in silence and I applaud Nic for having the courage to put his health first."