The 58-year-old star she has not applied for the alleged adoptions, reported AceShowbiz.
"I am in Malawi to check on the children's hospital in Blantyre and my other work with Raising Malawi, and then heading home. The rumors of an adoption process are untrue," the singer said.
It was recently reported that Madonna had appeared before a Lilongwe High Court judge with two unidentified children.
Madonna has adopted two children son David Banda, 11, in 2006 and daughter Mercy James, 11, in 2009 from the same country.