The 55-year-old singer sparked the rumours of starting skincare line by posting her bold picture on the bathroom floor on Instagram, reported Contactmusic.
"She's done for the day! Bath or shower? #MDNASKIN," she captioned the picture.
Her skincare line is claimed to be the new Japanese skincare brand, MDNA Skin, which will be launched on February 12.
Madonna already holds a fragrance range and a clothing line which she unveiled in 2010 with her daughter Lourdes.