The charkha (spinning wheel), with a minimum bid of 60,000 pounds, was used by Gandhi while he was in the prison in Pune and was later gifted to American Free Methodist missionary Revd Floyd A Puffer.
Puffer was a pioneer in Indian educational and industrial cooperatives. He invented a bamboo plow that was later adopted by Gandhi.
Gandhi presented the charkha to Puffer for his work in Colonial India.
Mullock's will auction over 60 Gandhi-related artifacts. Highlights include important documents, photographs and books, including an early publication advising German Jews to take up 'Satyagraha' during the holocaust.
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Under the British Raj, cotton grown in India was shipped to the UK for making garments, which were then shipped back to India and sold at a price that the people could not afford.
Since the traditional charkha was bulky and difficult to move, he needed an instrument that could be transported easily. During his imprisonment in Yerawda jail, Gandhi had devised the portable spinning wheel that folds and has a handle for carrying.
Gandhi often mentioned that his daily spinning was a form of meditation.
The sale will also include a number of historic items related to the Sikh and Mysore Kingdom.
Most notable of them are a 19th century painting of Tipu Sultan, a British school painting of the Sultan's daughter dated 1837, an early account dating to 1805 of Maharajah Ranjit Singh, the lion of Punjab and a rare miniature Koran printed for Muslim soldiers who fought alongside allied forces in the First World War.