The former state chief minister, who was till now discharging his duty as BJP Vice-President, became a frontrunner to assume the charge as the state party president, after the Supreme Court declined to intervene and lift a Karnataka High Court stay on his prosecution in a case under the Prevention of Corruption Act.
The Lingayat leader will assume charge from Prahlad Joshi, whose term ended in October but was extended till today because of zilla panchayat elections.
Speaking to reporters in Delhi, Yedyurappa said his main task as state party president would be to uproot the "corrupt" Congress regime from Karnataka.
"My task as the chief will be to throw out the corrupt Congress rule in Karnataka," he said after thanking National BJP President Amit Shah and Prime Minister Narendra Modi for giving him the responsibility.
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"I will discharge my duty as the state party president with honesty and sincerity. I thank Amit Shah and Prime Minister Narendra Modi, and several other leaders to have bestowed faith in my leadership, and I would like to take all the leaders alongside in the state," he said.
In January, the Karnataka High Court had quashed 15 FIRs filed against the senior BJP leader for alleged illegal denotification of lands based on a CAG report.
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Yeddyurappa was not allowed to lead the party in the run up to the 2013 state Assembly elections due to pending corruption charges, which saw him landing in jail in 2011.
Frustrated and disappointed at not getting the responsibility of leading theparty ahead of elections, Yeddyurappa formed his own party - the Karnataka Janata Paksha.
He returned to the party and campaigned extensively to ensure a victory in Lok Sabha elections, where the party won 17 out of the state's 28 constituencies.
Because of the pending corruption charges, he was kept out of the Union ministry. The party pacified him by giving him party vice-president's post.
Yeddyurappa was accused of illegally denotifying land in favour of his relatives.
Asked about pending corruption cases against him, Yeddyurappa said, he was confident of getting his name cleared from them as well.
Meanwhile, several state party leaders expressed happiness over Yedyurappa's appointment as the state unit chief.
Calling Yeddyurappa a "friend", Ananth Kumar claimed utilising his experience, BJP will once again come to power in Karnataka in 2018.
"Yeddyurappa is a mass leader; he is also farmers' leader, so his appointment will create a new atmosphere and confidence among party workers. This also shows BJP has taken upcoming elections seriously. I congratulate Yeddyrappa."
Expressing joy over Yeddyurappa's appointment his confidante and MP Shobha Karandlaje said he will emerge as a force in organising the party and fight the "Siddaramaiah government's misrule."
"He has the strength to fight the elections that is just two-and-half years away, he is a fighter. I believe that BJP will come back to power under his leadership," she said.