The main contenders are Congress-led-UDF candidate P K Kunhalikutty of Indian Union Muslim League, CPI-M candidate M B Faizal of ruling LDF and BJP's N Sreeprakash. Six independents are also in the fray.
There are more than 1100 polling stations in the constituency with a total electorate of 13,12,693.
The seat fell vacant following the death of former Union Minister and IUML leader E Ahamed.
The high voltage campaign saw workers of UDF, LDF and BJP engaged in hectic canvassing.
In the 2014 Lok Sabha polls, Ahamed had won the seat by a margin of 1,94,739 votes against CPI(M)'s P K Sainaba.
UDF sought votes to protect secularism and strengthen secular forces at the national level while LDF attacked BJP on various issues.