"In the past few days I have been the target of attacks from all sorts of individuals wanting a few minutes of fame and media attention at my expense," Mandla said at a nationally televised press conference held at a grass thatched public hall in the remote village of Mvezo where he is chief.
"At the moment it seems that anyone and everyone can come and say 'I am a Mandela' and demand to be part of decision-making in this family. Individuals decided to jump on the Mandela waggon," he added, before launching personal attacks on a number of his relatives.
The icon's ex-wife Winnie, who has regularly visited him in hospital, "has no business in the matters of the Mandelas," he added.
He also lashed out at his own brother Ndaba for claiming he was born out of wedlock.
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"I don't want to hang out our dirty linen as a family in public but he knows very well that my father impregnated a married woman of which he is the result of that act... As for the remaining of my two brothers we all know that they are not my father's children."
The targets of his anger jointly took Mandla to court to force him to return the remains of the three Mandela children to the revered leader's childhood village of Qunu, from the grandson's estate in the village of Mvezo about 30 kilometres away in the Eastern Cape province.
In dramatic scenes on Wednesday, authorities forced open the gates to Mandla's estate to exhume the remains.
Mandla said he had been surprised by the court order and had moved the graves "after following all the rituals and protocols".
The exhumed remains were due to undergo forensic tests today before reburial in Qunu.