"He was the one who really helped us break the conspiracy of silence," Michel Sidibe, the executive director of UNAIDS, told AFP in a telephone interview.
"His legacy is that of non-discrimination, inclusiveness, and making sure that we will continue to fight for the rights of people without rights... That is what he brought to the fight against HIV/AIDS," he added.
Mandela, who spent 27 years behind bars for his struggle under white minority rule and went on to become South Africa's first black president, became a leading AIDS campaigner after completing his single term in office.
Mandela among other things led the push for HIV sufferers to be given anti-retroviral drugs in South Africa, and launched a campaign for all governments to declare a global AIDS emergency, insisting that fighting the deadly illness was an issue of human rights.
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"Fighting discrimination ... And believing in inclusiveness and respecting the dignity of people, that is really what he brought (to the fight against) HIV/AIDS in the 21st century," Sidibe said.
Current President Jacob Zuma was similarly pilloried for telling a court hearing that he could not have HIV/AIDS after having sex with a positive partner, because he washed after sex.