According to a copy of the resignation letter which was made available to the press tonight, Jayentakumar Singh, an NPP leader, resigned yesterday.
Chief Minister Nongthombam Biren Singh, however, told PTI that he neither received the health minister's resignation letter nor has any information about it.
Nongthombam Biren Singh was sworn in as the Chief Minister of Manipur on March 15 along with eight other ministers, including Jayentakumar.
In the resignation letter to the Chief Minister, Jayentakumar said that he had been working with "certain visions".
Jayentakumar did not mention what kind of interference he had faced. He was also not available for comment.
He was elected from Keishamthong constituency in Imphal West district.