Public vehicles remained off the roads while major markets and educational institutions were forced to shut down in Kathmandu and other major cities in the strike called by hardlin CPN-Maoist (Chand), led by Netra Bikram Chand.
Hundreds of security personnel were deployed in Kathmandu and surrounding areas to prevent violence during the protest, the first national strike since a devastating quake hit the country in April.
The nation-wide strike was called to oppose the Constitution drafting process initiated by the four major political forces, the Nepali Congress, CPN-UML, UCPN-Maoist and Madhesi Peoples Rights Forum Democratic after inking a 16-point deal.
Nepal's Maoists struck a deal with rival parties on the new Constitution last month after years of bitter disagreement.
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But a breakaway faction of the party says the deal betrays the principles of the Maoists, who fought a decade-long civil war with the state that ended in 2006 and led to the abolition of a centuries-old feudal monarchy.
Lipu-Lekh Pass, the last point of Nepal's border with China and India and known as an ancient route for traders and pilgrims transiting between Nepal and Tibet, is a far western point, near Kalapani, which is a disputed border area between Nepal and India.
During Prime Minister Narendra Modi's China visit in May, India and China agreed to expand border trade at Lipu-Lekh Pass.
The bandh enforcers today also vandalised a passenger bus in Maharajgunj and a milk-van in Gongobu, police said.