Cho was officially announced as the latest addition to the E! series on Twitter, ahead of "Fashion Police" relaunch next month, reported NBC.
"We are so excited to officially welcome @MargaretCho to the #FashionPolice family," a tweet on the Fashion Police account read.
Cho completes a panel that also includes television producer Melissa Rivers, journalist Giuliana Rancic and celebrity stylist Brad Goreski.
The lineup of the E! series has been in flux for over a year, due to a controversy that erupted at the 2015 Academy Awards.
Her departure was quickly followed by Kathy Griffin, who had been brought in as a replacement for the late Joan Rivers.
"Fashion Police" was subsequently put on hiatus by E!, but will return on January 11 to break down trends from the Golden Globe Awards.