The 46-year-old songstress will make her long-awaited debut on the hit series' October 5 episode, reported E! online.
Carey will take on the role of Kitty, a mega-superstar who comes to Empire to collaborate with Jamal Lyon (Jussie Smollett) on an explosive new song.
When the duet encounters obstacles, Kitty helps Jamal dig deep to overcome personal difficulties and reach a musical breakthrough.
The "We Belong Together" hitmaker talked about possibly guest starring on the Fox hit drama, back in May, where she said her friend Lee Daniels, co-creator of the series, knew she wanted to do the show.