The 41-year-old, who plays a man whose teddy bear comes to life in the cheeky comedy, said he felt silly filming the key fight scene with a stuffed bear, reported Contactmusic.
"We choreographed it, but you're just in there flailing away at yourself. He's [Seth] like, 'OK, now he kicks you in the balls and now he does this.' I felt pretty silly," he said.
The scene took three days to film and saw Wahlberg wrestling with empty space or a prop until the teddy could be edited using CGI.
But "Family Guy" creator MacFarlane was thrilled with the end result.
"If you look at the raw footage, Mark's just going like this strangling himself with a pair of teddy bear arms attached to nothing.
"It gives you a sense of how good he is and how much he was able to sell the fact that he's fighting this imaginary character, because it really came together very well, I think," MacFarlane said.