The rupee was on a higher footing at 67.07 against the dollar, which stemmed the losses.
The 30-share barometer opened higher and rose further before profit-booking kicked in, which pulled it down to 24,623.34 at the close, a loss of 170.62 points, or 0.69 per cent.
The index had risen about 1,792 points in the past six sessions, its longest winning run since October last year.
Intra-day, it shuttled between 7,447.40 and 7,547.10.
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"The market capped the winning streak as anxiety over ECB policy meet led to profit booking. ECB is expected to provide a stimulus... Additionally, concerns over Chinese economy and swing in oil prices are adding to volatility," said Vinod Nair, Head-Fundamental Research, Geojit BNP Paribas.
The upmove in the previous six sessions mostly came on the back of continued foreign fund inflows and expectations that RBI would reduce the policy rate.
Moreover, a mixed closing at other Asian markets and a lower opening in Europe showed up in sentiment.
Investors waited for a policy update from the European Central Bank.
Shares of BHEL melted the most falling 2.93 per cent to Rs 104.50, followed by RIL (2.92 per cent) at Rs 1,011.50.
The country's second-largest IT exporter Infosys too slid 2.51 per cent to Rs 1,148.90 after reports that some of its founders sold off shares.
Other that contributed to the fall include GAIL, L&T, SBI, ITC, Axis Bank, Dr Reddy's, M&M and Hero MotoCorp.
The BSE capital goods index took the biggest knock, down 1.70 per cent, followed by IT 1.33 per cent, technology 1.21 per cent, oil and gas 1.05 per cent and realty 1.04 per cent.
In line with the overall trends, the broader markets witnessed selling, with the mid-cap index declining 0.32 per cent and small-cap shedding 0.18 per cent.
Back home, out of the 30-share Sensex pack, 18 scrips
ended higher.
Major gainers were Dr Reddy's (3.04 pc), Axis Bank (2.22 pc), HUL (1.93 pc), L&T (1.87 pc), GAIL (1.26 pc), HDFC (1.20 pc), Infosys (1.12 pc), BHEL (1.10 pc), Bharti Airtel (0.79 pc), Lupin (0.63 pc), HDFC Bank (0.36 pc) and SBI (0.34 pc).
Among BSE sectoral and industry indices, capital goods rose 1.48 per cent followed by consumer durables (0.68 pc), bankex (0.62 pc), finance (0.54 pc), healthcare (0.53 pc), IT (0.52 pc), realty (0.47 pc) and teck (0.47 pc).
The market breadth turned negative as 1,334 stocks ended lower, 1,277 closed higher while 153 ruled steady.
The total turnover fell to about Rs 2,348 crore from Rs 2,467.95 crore yesterday.