Studies have suggested that married people are healthier than those who are single, divorced or widowed.
The new study provides the first biological evidence to explain how marriage impacts health.
Researchers found that married individuals had lower levels of the stress hormone cortisol than those who never married or were previously married.
These findings support the belief that unmarried people face more psychological stress than married individuals.
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"It's is exciting to discover a physiological pathway that may explain how relationships influence health and disease," said Brian Chin, a PhD student at Carnegie Mellon University in the US.
Over three days, researchers collected saliva samples from 572 healthy adults aged 21-55. Multiple samples were taken during each 24-hour period and tested for cortisol.
The results showed that the married participants had lower cortisol levels than the never married or previously married people across the three day period.
Those who were married showed a faster decline, a pattern that has been associated with less heart disease, and longer survival among cancer patients.
"These data provide important insight into the way in which our intimate social relationships can get under the skin to influence our health," said Sheldon Cohen, professor at Carnegie Mellon University.
The research was published in the journal Psychoneuroendocrinology.
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