Branagh, who first brought the play to Manchester International Festival two years ago, before taking it to New York (where it caught the attention of Scorsese) in 2014, will reprise his role as the fatally ambitious Shakespearean anti-hero, reported Telegraph.
Branagh and Scorsese are also hoping to reunite as many of the original cast, which included "Doctor Who" star Alex Kingston as Lady Macbeth, as possible.
The film is expected to be more of a documentary piece than a straight Macbeth adaptation, following Branagh and his actors as they perform at Leavesden across a period of several weeks.
"Cinderella" stars Lily James and Richard Madden and Judi Dench are among the actors joining the company.