The 75-year-old director, who is reuniting with frequent collaborators Robert DeNiro and Joe Pesci on the Jimmy Hoffa disappearance film, announced the news on Instagram.
"That's a wrap! Thank you to the many people who made this possible. #iheardyoupainthouses #theirishman," Scorsese wrote.
The trio has previously delivered three masterpieces together, namely "Raging Bull", "Goodfellas" and "Casino".
Al Pacino will play Hoffa in the movie set in late 1970s to DeNiro's Frank "The Irishman" Sheeran and Pesci's mafioso Russell Bufalino.
Sheeran was a leading figure in the corruption of labour unions by organised crime and was said to be linked to Bufalino crime family. Shortly before his death, he claimed to have killed Hoffa.
The film also stars Anna Paquin, Bobby Cannavale, Harvey Keitel and Ray Romano in key roles.
It is expected to be released on Netflix next year.