The 73-year-old actor is best known for his work in films like 'Apocalypse Now', 'Gandhi' and 'The Departed'.
"I am truly honoured to accept the Dubai International Film Festival's Lifetime Achievement Award and looking forward to celebrating the region's gifted cinematic storytellers," Sheen said in a statement.
One of the most accomplished actors in Hollywood, Sheen has acted in more than 80 films including his most celebrated movie 'Apocalypse Now' with Francis Ford Coppola.
The actor h ad an equally fulfilling career on television with his six time Emmy nominated performance as President Josiah Bartlet in 'The West Wing'. Sheen won six of his eight Golden Globe nominations and two individual SAG awards for the White House series.
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"Martin Sheen is a cinematic legend whose remarkable career has spanned five decades. In that time he has brought to life a huge variety of compelling, intelligent and wonderfully engaging characters on the big and small screen. We are honoured to present Martin Sheen with a DIFF Lifetime Achievement Award and we look forward to welcoming him to Dubai," said DIFF Chairman Abdulhamid Juma.
Previous Lifetime Achievement award has gone to stalwarts of Indian cinema industry like Amitabh Bachchan, Shah Rukh Khan, Yash Chopra, Subhash Ghai and Maniratnam.
Other winners are Omar Sharif, Faten Hamamah, Adel Imam, Jameel Rateb, Sabah, Morgan Freeman, Sean Penn, Daoud Abdel Sayed, Youssef Chahine, Rachid Bouchareb, Souleymane Cisse, Nabil El-Maleh, Oliver Stone, Danny Glover, Terry Gilliam, Michael Apted and Mahmoud Abdel Aziz.