The 29-year-old actress will star opposite John Goodman in Dan Trachtenberg's microbudget thriller, reported Variety.
Trachtenberg is best known as the director of short fan film 'Portal: No Escape'.
Formerly titled 'Valencia', the film centres around a woman who wakes up after a car accident to find herself in a cellar with a man who claims the world has been devastated by a nuclear attack.
Trachtenberg was linked last year to the long-gestating adaptation of Brian K Vaughan and Pia Guerra's acclaimed comic 'Y: The Last Man'.
Winstead will next be seen with Jeremy Renner in 'Kill the Messenger'.