John Herrell of the Lake County Sheriff's Office said early today there were no fatalities despite massive blasts that ripped through the Blue Rhino propane plant late yesterday night.
Officials initially scrambled to find more than a dozen employees after the explosions.
"Management is comfortable saying all of those they knew were there tonight have been accounted for," he said.
Fire Chief Richard Keith said possible causes of the explosion may be either equipment malfunction or possibly human error. Sabotage was not suspected.
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The Blue Rhino plant, which is northwest of Orlando, refilled propane tanks typically used for barbecues and other uses. There were some 53,000 20-gallon (76-litre) tanks at the plant yesterday.
Herrell said a crew of 24 to 26 people was working the overnight shift when the explosions occurred around 10:30 pm local time yesterday.
Today morning, smoke still billowed from a storage container on the property, which consists of a couple of warehouses next to each other.
Officials said hoses designed to spray water on the large tanks in case of fire, didn't go off as planned.
Firefighters had to wait about four hours before they could go near the fire because the conditions were so dangerous.
Video footage on WESH-TV in Orlando showed fires burning through trucks used to transport propane tanks, which were parked at the plant. The fire sent plumes of smoke into the air hours after the blast.
According to the Leesburg Daily Commercial, the plant was built in 2004 and employs fewer than 50 people.