The winter storm brought sub-zero wind chills and ushered in dangerously cold temperatures, creating risky conditions on roads for commuters.
Authorities ordered the closure of interstate highways and airports were shut down, leading to the cancellation of thousands of flights.
New York's John F Kennedy Airport was officially closed this morning while Boston's Logan International remained effectively shut down.
Schools across the northeast, including all public schools in New York City, were closed today.
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With heavy snow, gusts of up to 35 mph and wind chills from 5 to 15 below zero, de Blasio urged New Yorkers to exercise caution in going outdoors, refrain from any unnecessary travel and utilise public transit.
Nearly 2,500 personnel are on the streets clearing the huge accumulation of snow. The top accumulations so far are 6.5 inches.
High winds will continue to blow plowed snow back into the streets, requiring additional passes.
Massachusetts Governor Deval Patrick urged residents to stay indoors and be aware of frostbite and hypothermia symptoms saying, "That is a very, very dangerous set of circumstances."
About 2,000 flights were cancelled today in addition to a similar number of cancellations yesterday, according to flight tracking website FlightAware.
Southwest Airlines and AirTran Airways said they were cancelling flights at Chicago's Midway International Airport and another 3,200 daily Southwest flights and 400 daily AirTran flights across the country were affected.