Maternal obesity, poor nutrition impairs fertility in daughter

Maternal obesity and poor nutrition during pregnancy may affect the egg reserves of female offspring and increase the risk of fertility problems in daughter, a new study has found.
This discovery improves scientific understanding of the long-term, generational, effects of obesity and poor nutrition, researchers said.
This understanding is the first step toward devising interventions to protect the fertility of females who experienced very difficult womb environments, they said.
"Infertility can have devastating impacts on individuals and families, and our study will help to better identify women who are at risk of experiencing problems with their fertility," said Catherine Aiken, a researcher from the University of Cambridge in UK.

"We hope to be able to devise ways to maintain future fertility for children who faced a very difficult nutritional environment in the womb," Aiken said.
Researchers used mice fed either a high-fat and high-sugar (obesogenic) diet or a normal healthy diet during pregnancy.

After which, their female offspring were weaned onto the same obesogenic diet or normal diet. The results showed low egg reserves in all of the daughters whose mothers ate a high-fat and high-sugar diet, regardless the daughters' diet.
To find the cause of the low egg reserves, researchers examined the ovaries of the daughters and discovered changes that disrupted the normal protection against damaging free radicals in the ovaries, as well as energy production.

"It has of course long been known that the intrauterine environment is critical and also that maternal nutritional deprivation in particular can have very adverse effects on the offspring," said Thoru Pederson, Editor-in-Chief of The FASEB Journal, where the research was published.
"However, this study shows that caloric excess also has adverse consequences and that to the extent the effect is reduced ovulation, it constitutes a transgenerational defect that would be evolutionarily severe," Pederson said.