In the episode, "The Martian" star, 44, is having a heated discussion with producer Effie Brown about the importance of diversity in Hollywood, often interrupting and talking over her, reported Us magazine.
She is trying to explain that the only black character in the film is a prostitute getting beaten by her pimp, urging the all-white team to make sure the character doesn't fall into a racist stereotype.
Unfortunately, Damon seemingly suggests that diversity behind the camera does not matter.
Brown looks shocked before saying, "Wow, okay."
Soon the hashtag "#Damonsplaining" started trending online.
"Matt Damon is... Still a White man, y'all," one person tweeted while another wrote, "The struggle to NOT talk over a Black woman tends to be really strong for many of them.