The Tony Award winning actor will join the comedy show as a neurotic new friend of regular character Phil Dunphy (played by Ty Burrell), reported Ace Showbiz.
No other details of his character have been released so far.
The "Ferris Bueller's Day Off" star joins Greg Kinnear, Ellen Barkin, Minnie Driver, Kevin Hart, Philip Baker Hall and Nathan Lane who have all been slated to appear in the fourth season of the Emmy-winning comedy.
Broderick has previously guest starred on '30 Rock' and 'Louie', and most recently lent his voice for an episode of animated show 'Adventure Time'.
The 50-year-old actor's wife Sarah Jessica Parker will also appear on the small screen when she stars in the latest series of 'Glee'.
'Modern Family' season 4 will kick off from September 26.