Coming into the game after a loss to Punjab, Karnataka piled up 353 for 6 in 50 overs after being put in and bowled Odisha out for 220 in 41 overs.
In other Group A games, Baroda defeated Railways by 192 runs and Punjab beat Assam by 69 runs.
Mayank Agarwal and Nair added 190 runs for the opening wicket to put Karnataka on track for a big score.
Agarwal scored 102 from 94 balls with two sixes and ten fours while Nair hit 100 from 111 deliveries with 12 fours.
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Odisha began well as Rajesh Dhuper (53) and Anurag Sarangi (58) came up with half-centuries each to lay an ideal platform. However, Suchith (5 for 34) spun a web around the Odisha batsmen to send them hurtling to defeat.
Meanwhile, Baroda thrashed Railways thanks to a blistering 161 by captain Deepak Hooda and Kedar Devdhar's 111.
After amassing 357 for 7 in 50 overs, Baroda bowled out the opponent for 165 in 37 overs.
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