His latest film "Gold," directed by Stephen Gaghan, will also be screened at the festival on November 10, reported Variety.
The film, an adventure drama, revolves around Kenny Wells (McConaughey), a prospector desperate for a lucky break, who teams up with a geologist, played by Edgar Ramirez, and sets off on a journey to find gold in the uncharted jungle of Indonesia.
Post the screening McConaughey will be presented with the Caldwell Vineyards Maverick Actor Tribute for his outstanding contributions to the art of acting and cinematic story-telling.
"Matthew boldly inhabits each character that he plays on screen, and we are just delighted to showcase his latest film and to honor him at the festival this year," said Napa Valley Film Festival co-founder and director Marc Lhormer.
The festival will run from November 9 to 13.