Ryan, 46, will be celebrated with a special screening of "Ithaca," her 2015 directorial feature film debut, reported Variety.
A five-day program dedicated to the best in film, food, wine and spirits will also honour screenwriter and SIFF supporter Robert Mark Kamen, whose writing credits include the "Transporter," "Taken" and "Karate Kid" franchises.
The festival will open with Joachim Trier's Jesse Eisenberg-starring drama "Louder Than Bombs" and conclude with the French romantic comedy "The Sense of Wonder."
SIFF runs March 30 to April 3.