The 51-year-old actress, who was last seen doing a regular role in 1985's 'Wildside', will play a former hotshot New York editor in the sitcom, said the Hollywood Reporter.
Marc Lawrence would pen the script.
Ryan will executive produce the project with manager Jane Berliner for Universal Television and Lawrence's Reserve Room Productions.
The actress, who starred in romantic comedies like 'When Harry Met Sally' and 'You've Got Mail', has been making guest appearances in shows like 'Web Therapy' and 'Curb Your Enthusiasm' recently.