The 52-year-old actress has hit films like When Harry Met Sally', 'Sleepless in Seattle', 'City of Angels', 'You've Got Mail' and 'Kate & Leopold' to her credit, reported Contactmusic.
"My main aim, at 18, was to become a journalist. I only started acting - in commercials - to pay my way through college in New York," Ryan said.
The actress was intimidated in the initial days of her career.
"I was 19 when I was in my first film, 'Rich And Famous'. I played Candice Bergen's daughter and only had about ten lines, which I would repeat constantly every night," Ryan said.