Banderas, 54 and the 57-year-old actress have signed the divorce documents making their separation official, reported TMZ.
According to the court records, both signed the necessary legal documents and Melanie has asked for full custody of their daughter, Stella.
She has also asked for spousal support. However, with their daughter turning 18 last year the custody issue no longer exists.
For Griffith, who has been previously married Don Johnson (twice) and Steven Bauer, it will be fourth divorce. And second time for "Desperado" actor who was married to Ana Leza in past.