Memory-related brain activity loses cohesion with age: study

Brain regions that synchronise their activity during memory tasks become smaller and more numerous as people age, according to a new study.
Researchers from Princeton University in the US have found a novel method to characterise and compare the brain dynamics of individual people.
Typically, research on brain activity relies on average brain measurements across entire groups of people.
The researchers used functional magnetic resonance imaging (fMRI) to record healthy people's brain activity during memory tasks, attention tasks, and at rest.
For each person, fMRI data was recast as a network composed of brain regions and the connections between them.

Researchers then used this network to measure how closely different groups of connections changed together over time.

They found that, regardless of whether a person is using memory, directing attention or resting, the number of synchronous groups of connections within one brain is consistent for that person. However, between people, these numbers vary dramatically.
During memory specifically, variations between people are closely linked to age.
Younger participants have only a few large synchronous groups that link nearly the entire brain in coordinated activity, while older participants show progressively more and smaller groups of connections, indicating loss of cohesive brain activity - even in the absence of memory impairment.

"This method elegantly captures important differences between individual brains, which are often complex and difficult to describe," said Elizabeth Davison from Princeton University.
"The resulting tools show promise for understanding how different brain characteristics are related to behaviour, health, and disease," said Davison.
The study was published in the journal PLOS Computational Biology.