Merkel will embark on the trip Sunday and meet US President Barack Obama in Washington and Canadian Prime Minister Stephen Harper in Ottawa.
"Beyond G7 issues, current topics in international politics including the Ukraine crisis, the approach to Russia, the fight against terrorism (ISIS), Afghanistan and Iran will also be discussed," the spokeswoman, Christiane Wirtz, said in a statement.
She said economic and trade policy as well as climate issues would also be on the agenda in both capitals.
Efforts to push through the world's biggest-ever free trade deal, known as the Transatlantic Trade and Investment Pact (TTIP), are expected to figure prominently during the three-day tour.
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US and EU negotiators began their eighth round of talks on the pact in Brussels today, which after nearly two years remain bogged down by public opposition.
The fate of debt-mired Greece is also expected to play a major role in the talks with Obama, who yesterday warned that imposing tough austerity requirements on Athens could backfire on its creditors.
Germany is the effective paymaster for Greece's bailout programmes and Merkel has insisted that Athens stick to a strict regimen of budget cuts in exchange for assistance.
Merkel will host the G7 summit meeting June 7 and 8 in Bavaria.