"We take note of the British people's decision with regret. There is no doubt that this is a blow to Europe and to the European unification process," she said.
But "what the consequences of this would be... Would depend on whether we - the other 27 member states of the EU - prove to be willing and able to not draw quick and simple conclusions from the referendum in Great Britain, which would only further divide Europe," said Merkel.
Recalling the founding aim of the EU, Merkel urged Europeans to "never forget that the idea of European unity was an idea of peace.