The Argentine made his bow as a 17-year-old in a 1-0 win at city rivals Espanyol on October 16, 2004. Now he is preparing to face Eibar at the Camp Nou tomorrow needing just two goals to equal Telmo Zarra's all-time Spanish top-flight record of 251, set in the 1950s.
Messi, who told fans he was "constantly trying to improve and win more titles," has been back at his best in the early weeks of this season to help the Catalans to the top of La Liga with six wins and a draw in their opening seven games.
"To go into the Clasico in the best possible condition we need to win on Saturday," said left-back Jordi Alba.
"If we don't win this one we we will suffer when we play in Madrid. Eibar have had good results away from home and if we don't play at a high level they will make it difficult for us."
The entire population of the town could fit into the Camp Nou three times and still leave empty spaces, but Gaizka Garitano's side, in their debut top-flight season, currently have as many points as their far more illustrious neighbours Athletic Bilbao and Real Sociedad combined.
"This is football and it's clear that if we defend well, don't make mistakes and get a bit of luck, we can come away with at least a point," said optimistic midfielder Dani Nieto, formerly of Barcelona B.