A first-half goal from in-form Napoli striker Gonzalo Higuain settled a low-key encounter in San Juan last night, with two-time world champions Argentina dominating possession and shots.
But the result was overshadowed by an alarming incident involving Messi midway through the second half that forced the Barcelona superstar to leave the field clutching his lower back in pain.
The five-time FIFA World Player of the Year appeared to be hurt after a heavy aerial collision with an opposing player in the 59th minute.
Messi was taken to hospital to assess the nature of the injury, the Argentina Football Association said in a statement.
More From This Section
"Messi suffered trauma to his lower back on the left side and ribcage in the same area. He is being examined in a local hospital for a more thorough diagnosis," the statement said.
"It's too early for me to say anything more at this
stage," Martino told a post-match news conference.
However, any injury to Messi will be a huge blow to Argentina as they prepare for their opening Copa America Centenario match against Chile in California on June 6.
The 28-year-old Argentina captain missed two months of last season's club campaign for Barcelona after suffering a serious knee injury in September.
Messi is also due to return to Spain this weekend to attend a hearing in his tax fraud trial, before then jetting off to California to reunite with the Argentina squad.
Earlier in yesterday's match, Higuain's goal in the 31st minute had settled the encounter for the hosts.
Argentina had earlier threatened the Honduras goal when Messi played in Angel Di Maria only for the Paris Saint-Germain forward to shoot over the bar.
Manchester City defender Nicolas Otamendi also went close on 28 minutes, volleying just wide from Di Maria's corner.
Higuain fired the Argentines ahead just after the half hour, and only a fine close-range save from Escober prevented Manchester United defender Marcos Rojo from making it 2-0 on 39 minutes, his shot from Erik Lamela's pass parried away at the near post.