Napoli striker Gonzalo Higuain is expected to return to Sabella's starting line-up as the two-time winners look to seal their place in the second round of the World Cup with a victory over Iran.
Higuain came on as a substitute to set up Messi to score just his second ever World Cup goal as Argentina got their campaign off to a winning start against Bosnia and Herzegovina in Rio on Sunday.
"We are Argentina and I think we need to concentrate on ourselves without fixating on who we are playing," said the four-time World Player of the Year.
"We feel more comfortable with two up front and me behind because it makes it easier to counter-attack and, because we have more people in attack, we have more possibilities."
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Messi eased some of the pressure on his shoulders to finally deliver his best form at a major tournament for his country with his stunning effort in the 2-1 win over Bosnia.
"In the first-half I found it difficult to get a hold of the ball and when I did I was very far from goal.
"The truth is when I did have the ball I lost it a number of times and at other times I was playing it backwards. I was annoyed at not being able to play the game I had planned.