Growing economic integration across the region was also enabling cross-border criminal networks to cooperate in peddling amphetamine-type stimulants and so-called "legal highs", the United Nations Office on Drugs and Crime (UNODC) said in a report.
The study, which was released in Bangkok, covers Southeast Asia, East Asia and Oceania, but excluded South Asia.
Between 2008 and 2013, the last year covered by the UNODC figures, regional seizures of methamphetamine -- known colloquially as meth -- rose nearly four-fold from 11 to 42 metric tonnes.
The drug, a potent stimulant, tends to come in two forms, a powerful crystalline variant known as "ice" or crystal meth, and the usually less pure tablets.
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Between 2008 and 2013 crystal meth seizures doubled, from seven to around 14 tonnes.
But meth tablet seizures grew eight fold, from 30 million tablets in 2008 to more than 250 million in 2013.
Long popular in the poorer Mekong region countries of Cambodia, Laos, Myanmar, Thailand and Vietnam as an affordable high -- often for people working long hours such as truck drivers -- yaba is finding new consumers in wealthier countries.
"This significant increase of seizures might partly be the result of effective law enforcement measures, " the study said.
But the rise "also points to expanding manufacture and an increase of trafficking to and through the region as the synthetic drug market is becoming increasingly interconnected with other regions."
These are laboratory produced chemical compounds that mimic the effects of popular recreational drugs like ecstasy and cannabis but are not yet controlled by international drug conventions.
Both southern China and Myanmar remain major regional synthetic drug production hotspots.