Garcia Marquez, who died in Mexico City on Thursday aged 87, will be eulogized in the domed Bellas Artes Palace, a cultural center where Mexico pays tributes to its late artistic icons.
Colombian President Juan Manuel Santos is heading to Mexico to take part in the ceremony alongside Mexican leader Enrique Pena Nieto and Garcia Marquez's wife and two sons.
The veteran journalist first moved to Mexico in 1961 and it was here that he wrote his seminal novel, "One Hundred Years of Solitude," which was published in 1967.
The ceremony at Bellas Artes, which starts at 2100 GMT, will include a string quartet that will perform music by Hungarian composer Bela Bartok.
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"Garcia Marquez never became a Mexican national but he has Mexican family: His sons, grandchildren as well as his house and friends," said Jaime Abello, director of the Ibero-American New Journalism Foundation founded by Garcia Marquez.
His biographer, British writer Gerald Martin, said he understood the secular nature of the ceremony because Garcia Marquez was not a religious man.
"But he was a man who respected other people's beliefs, like his mother. Almost his entire family was very Catholic," Martin told Colombia's Caracol radio.
"He joked that he didn't believe in god but feared him a lot," said the author of "Gabriel Garcia Marquez: A Life."
His native Colombia will hold its own ceremony at Bogota's cathedral on Tuesday for the man Santos has hailed as "the greatest Colombian of all time."
The family has not said where the author's final resting place will be but Colombia hopes that the family will divide Garcia Marquez's ashes between his homeland and Mexico.