Manan Vohra, who scored 95 against Sunrisers Hyderabad is out due to sickness while Marcus Stoinis, Shaun Marsh, Gurkeerat Singh and Swapnil Singh come into the XI.
The players left out are Vohra, David Miller, Eoin Morgan and KC Cariappa. MI kept their side unchanged.
Kings XI Punjab: Glenn Maxwell (captain), Hashim Amla, Shaun Marsh, Marcus Stoinis, Wriddhiman Saha, Axar Patel, Gurkeerat Singh, Swapnil Singh, Mohit Sharma, Sandeep Sharma, Ishant Sharma
Mumbai Indians: Rohit Sharma (capt), Parthiv Patel, Jos Buttler, Nitish Rana, Kieron Pollard, Hardik Pandya, Krunal Pandya, Harbhajan Singh, Mitchell McClenaghan, Lasith Malinga, Jaspreet Bumrah.